Syracuse vs. Duke odds, line: 2021 college basketball picks, Feb. 22 predictions from proven computer model

Get ready for an ACC battle as the Duke Blue Devils and the Syracuse Orange will face off at 7 p.m. ET on Monday at Cameron Indoor Stadium. Duke is 10-8 overall and 7-4 at home, while Syracuse is 13-6 overall and 2-5 on the road. Duke has won the last three meetings between the two teams. The Blue Devils are favored by 5.5-points in the latest Duke vs. Syracuse odds from William Hill Sportsbook, and the over-under is set at 149.5. Before entering any Syracuse vs. Duke picks, you’ll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of over $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Duke vs. Syracuse. You can head to SportsLine to see its picks. Here are several college basketball odds for Duke vs. Syracuse:

• Duke vs. Syracuse spread: Duke -5.5
• Duke vs. Syracuse over-under: 149.5 points

What you need to know about Duke

The Blue Devils slipped by the Virginia Cavaliers on Saturday, 66-65. Matthew Hurt shot 5-for-8 from downtown and finished with 22 points. The Blue Devils have won three consecutive games. Duke held Virginia without a field goal in the final 3:48 of the game. 

Hurt is averaging 22.7 points over his last three games. Hurt is the only player in the nation shooting better than 56 percent from the field and over 46 percent from three-point range while making more than six field goals per game. Duke has won seven of the last 10 matchups against Syracuse. 

What you need to know about Syracuse

Meanwhile, Syracuse scored a win over the Notre Dame Fighting Irish on Saturday, 75-67.  The Orange overcame a 20-point deficit in the victory. Buddy Boeheim shot 6-for-10 from beyond the arc and finished with 29 points. The Orange have won three consecutive games. 

Syracuse leads the ACC and is sixth in the nation in free throw percentage (.797). The Orange lead the ACC in steals per game (9.2). Quincy Guerrier is second in the ACC in rebounds per game (9.4). 

How to make Syracuse vs. Duke picks

The model has simulated Duke vs. Syracuse 10,000 times and the results are in. We can tell you that the model is leaning over, and it also says one side of the spread has all the value. You can only see the pick at SportsLine.

So who wins Syracuse vs. Duke? And which side of the spread has all the value? Visit SportsLine now to see which side of the Syracuse vs. Duke spread to jump on Monday, all from the advanced computer model that has crushed its college basketball picks.