City have won 10 of their last 11 matches in the competition, with the sole defeat coming in a 2-0 defeat to Arsenal at Wembley in the semi-final last year.
Meanwhile, Birmingham enter the fixture in particularly dreadful form after losing in five of their last six matches.
Aitor Karanka’s side have not scored a single goal in their last three outings, and will be hoping that some FA Cup magic will come their way.
Here is everything you need to know:
When is it?
The fixture will kick-off at 1:30pm GMT at the Etihad Stadium.
How can I watch it?
The match will be streamed live on the BBC Sport website and iPlayer.
What is the team news?
Manchester City’s record goalscorer Sergio Aguero is set to make his first start for the club since October after recovering from a knee problem. Gabriel Jesus and Kyle Walker have both recovered from Covid, but the game comes too soon for Ederson.
Birmingham defenders Marc Roberts and Kristian Pedersen could play after returning to training following ankle and knee issues respectively. Caolan Boyd-Munce and goalkeeper Zach Jeacock remain injured.
Manchester City: Steffen, Walker, Harwood-Bellis, Stones, Mendy, Rodri, Gundogan, Foden, Mahrez, Aguero, Zinchenko
Birmingham: Prieto, Dean, Colin, Clarke-Salter, Friend, Clayton, Kieftenbeld, Toral, Bela, Hogan, Leko
Manchester City: 1/10
Birmingham’s form in the Championship has been awful, and so this clash against a Manchester City side in the ascendency just feels like bad timing. 4-0 City.
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